Pathogenetic Basis of the Development of Thrombophilia in Preeclampsia
DOI:
https://doi.org/10.51699/cajmns.v3i4.926Keywords:
preeclampsia, D-dimer, thrombophilia, hemostasisAbstract
In preeclampsia, soluble fibrin monomer complexes (FMFC), fibrin degradation products (PDF) and D-dimer are significantly increased, which indicates the presence of disseminated intravascular coagulation syndrome. The level of D-dimer in the blood is the most favorable prognostic indicator in the assessment of severe preeclampsia. Such a high level of thrombophilia allows us to consider it as the most important etiopathogenetic factor in the development of preeclampsia.
References
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2. Akhmedov F.K. Features of renal function and some indicators of homeostasis in women with mild preeclampsia// Europen Science Review. - 2015. - №4-5. - С. 58 - 60.
3. Akhmedov F.K., Negmatullaeva M.N., Kurbanova Z.Sh. Modern views on the problem of preeclampsia // A new day in medicine. - 2018. - № 1 (21). - S. 180-185.
4. Akhmedov F.K., Negmatullaeva M.N., Features of the state of central hemodynamics and hemostasis in pregnant women with preeclampsia of varying degrees and severity // New Day of Medicine. - 2020. - No. 1 (29) - S. 147-150.
5. Bargetzi, M. J. Interleukin-1 beta induces unterleukin-1 receptor antagonist and tumor necrosis factor binding protein in humans / M. J. Bargetzi, M. Lantz, C. G. Smith [et al.] // Cancer. Res. – 2017. – Vol. 53, № 17. – Р. 4010-4013.
6. Bowen, R. S. Hypoxia promotes interleukin-10 production by placental trophoblast cells from preeclamptic pregnancies / R. S. Bowen, Y. Gu, Y. Zhang [et al.] // J .Soc. Gynecol. Investig. – 2015. – Vol. 12, № 6. – Р. 428-439.
7. Carl, V. S. Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression / V. S. Carl, J. K. Gautam, L. D. Comeau [et al.] // J. Leukol. Biol. – 2014. – Vol. 76, № 3. – Р. 735-742
8. Cheranov, S. Y. TNF-α dilates cerebral arteries via NADPH oxidasedependent CA2+ spark activation / S. Y. Cheranov, J. H. Jaggаr // Am. J. Physiol. Cell Physiol. – 2016. – Vol. 290. – № 4. – Р. c964-c971.
9. Deshpande, S. S. Rac1 inhibits TNF-α-induced endothelial cells apoptosis: dual regulation by rective oxygen species / S. S. Deshpande, P. Angkeow, J. Huang [et al.] // FASEB J. – 2019. – Vol. 14, № 12. – Р. 1705-1714.
10. Dickensheets, H. L. Interleukin-10 upregulates tumor necrosis factor receptor type-II (p75) gene expression in endotoxine-stimulated human monocytes / H. L. Dickensheets, S. L. Freeman, M. F. Smith [et al.] // Blood. – 2017. – Vol. 90, № 10. – Р. 4162-4171.
11. Girard, S. IL-1 receptor antagonist protects against placental and neurodevelopmental detects induced by maternal inflammation / S. Girard, L. Tremblay, M. Lepage [et al.] // J. Immunol. – 2015. – Vol. 184, № 7. – Р. 3997-4005.
12. Granowitz, E. V. Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: IL-1 receptor antagonist inhibits lipopolysackharide-induced cytokine synthesis by human monocytes / E. V. Granowitz, E. Vannier, D. D. Poutsiaka [et al.] // Blood. – 2017. – Vol. 79, № 9. – Р. 2364-2369.
13. Hashii, K. Peripheral blood mononuclear cells stimulate progesterone production by luteal cells derived from pregnant and non-pregnant women: possible involvement of interleukin-4 and interleukin-10 in corpus luteum function and differentiation / K. Hashii, H. Fujiwara, S. Yoshioka [et al.] // Human. Reprod. – 2018. – Vol. 13, № 10. – Р. 2738-2744.
14. Hennessy, A. A deficiency of placental IL-10 in preeclampsia / A. Hennessy, H. L. Pilmore, L. A. Simmons [et al.] // J. Immunol. – 2019. – Vol. 163, № 6. – Р. 3491-3495.
15. Huang, H. Y. Interleukin (IL)-1β regulation of IL-1β and IL-1 receptor antagonist expression in cultured human endometrial stromal cells / H. Y. Huang, Y. Wen, J. S. Kruessel [et al.] // J. Clin. Endocrinol. Metab. – 2011. – Vol. 86, № 3. – Р. 1387-1393.
16. Juge-Aubry, C. E. Adipose tissue is a major source of interleukin-1 receptor antagonist upregulation in obesity and inflammation / C. E. Juge-Aubry, E. Somm, V. Giusti [et al.] // Diabetes. – 2013. – Vol. 52, № 5. – Р. 1104-1110.
17. Negmatullaeva M.N., Akhmedov F.Q., Tuksanova D.I. Modern diagnostics of markers of preeclampsia // Vestnik Tashkentskoy meditsinskoy akademii. - 2020. -№2 (94). - S. 145 - 147.
18. Negmatulleva M.N., Tuksanova D.I., Nosirova M.Sh., Akhmedov F.K. Features of the state of the circulatory system mother and fetus in the second trimester ofpregnancy in women with mitral stenosis ofrheumatic etiology// European Journal of Biomedical and Pharmaceutical sciences. - 2020. - №7(6). - P. 100 - 103.
19. Maniyozova G.M., Akhmedov F.K., Shamsieva T.T. Indicators of cytokines in pregnant women with antiphospholipid syndrome who received pregravadar preparation // New Day of Medicine. - 2020. - No. 2 (30/2). - S. 194-197.
20. Medvedev, BI Clinical and biochemical predictors of the development of preeclampsia / BI Medvedev, EG Syundyukova, SL Sashenkov // Obstetrics and gynecology. - 2013. - No. 5. - S. 30-35.
21. Maedler, K. Leptin modulates β-cell expression of IL-1 receptor antagonist and release of IL-1β in human islets / K. Maedler, J. Oberholzer, P. Bucher [et al.] // PNAS. – 2014. – Vol. 101, № 21. – Р. 8138-8143.
22. Matsuki, T. IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions / T. Matsuki, R. Horai, K. Sudo [et al.] // J. Experim. Med. – 2013. – Vol. 198, № 6. – Р. 877-888.
23. Solieva N.K., Negmatullaeva M.N, Sultonova N.A. Features Of The Anamnesis Of Women With The Threat Of Miscarriage And Their Role In Determining The Risk Group// The American Journal of Medical Sciences and Pharmaceutical Research. - 2020. - № 2(09). - P. 32-34.
24. Tuksonova D.I., Solieva N.K., Negmatullaeva M.N., Shamsieva T.I. The importance of immune status in miscarriage // News of dermatovenerology and reproductive health. - 2020. - No. 1. - S. 52 -54.
25. Tuksanova Dilbar Ismatovna and Solieva Nozima Karimovna. The value of the immune status in miscarriage // Evropean Journal of Pharmaceutical and Medical Research. - 2020. - №7 (6). - P. 117- 119.
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Published
2022-07-13
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Pathogenetic Basis of the Development of Thrombophilia in Preeclampsia. (2022). Central Asian Journal of Medical and Natural Science, 3(4), 45-50. https://doi.org/10.51699/cajmns.v3i4.926
