Rheological Behavior and Chemical Modification of Fluconazole-Containing Cellulose Derivative Systems

Shukurov A. I.; Sarymsakov A. A.; Vahobjonov A. A.

Authors

Shukurov A. I. Institute of Polymer Chemistry and Physics
Sarymsakov A. A. Institute of Polymer Chemistry and Physics
Vahobjonov A. A. Institute of Polymer Chemistry and Physics

Keywords:

Cellulose diacetate, rheology, viscosity, deacetylation, FTIR spectroscopy, electrospinning solutions, biomaterials

Abstract

Cellulose diacetate (CDA) solutions prepared in acetone–ethanol and acetone–glycerol solvent systems were investigated to determine their suitability for electrospinning applications. The influence of polymer concentration and solvent composition on rheological behavior was evaluated. An increase in CDA concentration led to a significant rise in viscosity, while the presence of glycerol enhanced intermolecular interactions and solution stability. The optimal rheological properties for fiber formation were observed at polymer concentrations of 7.5–10 wt.%. Surface modification of CDA was performed by alkaline deacetylation to improve hydrophilicity. Fourier-transform infrared spectroscopy (FTIR) confirmed the conversion of acetyl groups into hydroxyl groups, indicating successful deacetylation. The obtained results demonstrate the crucial role of solution rheology and chemical modification in tailoring CDA-based materials for biomedical and drug delivery applications.

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