Results of Treatment of Pulmonary Metastatic Disease in Cats With Mammary Carcinoma

Makhkamov Sarvar  Robertovich; Evgeny Aleksandrovich  Khimich

doi:10.51699/cajmns.v7i3.3294

Authors

Makhkamov Sarvar Robertovich Assistant Lecturer at the Tashkent Branch of Samarkand State University of Veterinary Medicine, Animal Husbandry and Biotechnology
Evgeny Aleksandrovich Khimich Oncologic Surgeon at the “Darel” Veterinary Clinic

DOI:

https://doi.org/10.51699/cajmns.v7i3.3294

Keywords:

mammary gland cancer, metastases, lungs, cats, chemotherapy, doxorubicin, carboplatin, mastectomy, palliative treatment

Abstract

Mammary gland cancer (MGC) is one of the most common malignant neoplasms in cats and is frequently associated with metastatic involvement of the lungs. The study included cats with stage III–IV mammary carcinoma that underwent surgical treatment combined with chemotherapy: doxorubicin (1 mg/kg) was administered in the first group, and carboplatin (260 mg/m²) in the second group. The time to onset of clinical signs of metastasis, mean survival time after detection of metastases, and the efficacy of palliative chemotherapy were evaluated. It was established that palliative chemotherapy for metastatic lesions of the lungs and pleura prolonged survival compared to animals receiving only symptomatic therapy; the mean survival time after detection of metastases ranged from 63 to 128 days, with no statistically significant differences between the two drugs. Palliative chemotherapy contributed to improved quality of life; however, the development of new therapeutic strategies, including targeted therapy and the use of early biomarkers of metastasis, remains a relevant objective.

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