Optimization of Hysteroscopic Diagnosis of Chronic Endometritis in Women With Reproductive Loss

Shokirova N. G.; Muratova N. D.

Authors

Shokirova N. G. "National Medical Center" Tashkent, Uzbekistan
Muratova N. D. "National Medical Center" Tashkent, Uzbekistan

Keywords:

Chronic endometritis, hysteroscopy, reproductive loss, recurrent pregnancy loss, CD138, endometrial biopsy

Abstract

Chronic endometritis (CE) is a significant factor in reproductive loss, including recurrent pregnancy loss and repeated implantation failure in assisted reproductive technology programs. Despite its high prevalence, diagnosing CE remains challenging due to its often asymptomatic course and the lack of strictly pathognomonic clinical signs. Hysteroscopy, combined with morphological and immunohistochemical examination of the endometrium, is considered a key tool for detecting the disease.

References

Ministry of Health of the Russian Federation, Clinical Recommendations: Habitual Miscarriage. Moscow, Russia: Ministry of Health of the RF, 2023.

Ministry of Health of the Russian Federation, Clinical Recommendations: Infertility. Moscow, Russia: Ministry of Health of the RF, 2022.

E. Cicinelli, M. Matteo, R. Tinelli, R. Lepera, A. Alfonso, and L. Indraccolo, “Chronic endometritis: A frequent cause of infertility,” Fertility and Sterility, vol. 103, no. 6, pp. 1548–1554, 2015.

K. Kitaya, T. Takeuchi, T. Mizuta, H. Matsubayashi, and T. Ishikawa, “Chronic endometritis and reproductive failure,” Reproductive Medicine and Biology, vol. 17, no. 3, pp. 229–241, 2018.

D. McQueen, J. Bernardi, and M. Stephenson, “Hysteroscopic findings in chronic endometritis,” Journal of Minimally Invasive Gynecology, vol. 21, no. 3, pp. 394–399, 2014.

P. E. Bouet, M. El Hachem, C. Monceau, P. Gariepy, and P. Kadoch, “Chronic endometritis in women with recurrent pregnancy loss,” Fertility and Sterility, vol. 105, no. 1, pp. 129–136, 2016.

I. Moreno, E. Cicinelli, I. Garcia-Grau, A. Gonzalez-Monfort, and C. Simon, “Evidence of chronic endometritis in recurrent implantation failure,” Human Reproduction, vol. 33, no. 9, pp. 1614–1624, 2018.

K. Kitaya and T. Takeuchi, “Immunohistochemical detection of CD138 in chronic endometritis,” American Journal of Reproductive Immunology, vol. 71, no. 5, pp. 446–453, 2014.

J. C. Kasius, S. Fatemi, B. Bourgain, and P. Devroey, “The diagnostic accuracy of hysteroscopy in chronic endometritis,” Human Reproduction Update, vol. 17, no. 1, pp. 105–114, 2011.

E. Johnston-MacAnanny, K. Hartnett, J. Engmann, and N. Nulsen, “Chronic endometritis and IVF outcome,” Fertility and Sterility, vol. 93, no. 2, pp. 437–441, 2010.

H. A. Taylor and L. Gomel, “The uterus and fertility,” Fertility and Sterility, vol. 89, no. 1, pp. 1–16, 2008.

M. Vitagliano, G. Saccardi, A. Noventa, and C. Di Spiezio Sardo, “Effects of chronic endometritis therapy on in vitro fertilization outcome,” Journal of Gynecologic Surgery, vol. 34, no. 2, pp. 89–95, 2018.

A. Di Spiezio Sardo, G. Spinelli, and M. Bramante, “Efficacy of hysteroscopy in improving reproductive outcomes,” Current Opinion in Obstetrics and Gynecology, vol. 27, no. 3, pp. 218–224, 2015.

R. Romero, D. Espinoza, and J. Mazor, “Can endometrial infection/inflammation explain implantation failure?” American Journal of Reproductive Immunology, vol. 61, no. 2, pp. 75–93, 2009.

K. Kitaya and H. Yasuo, “Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis,” Modern Pathology, vol. 23, no. 8, pp. 1136–1146, 2010.

J. Crum, Diagnostic Gynecologic and Obstetric Pathology, 3rd ed. Philadelphia, PA, USA: Elsevier, 2018.