Ultrasound Assessment of Renal Dysfunction as an Early Marker of Cognitive Impairment in Middle-Aged Patients with Dyscirculatory Encephalopathy

Mamurova Malikaxon Mirxamzayevna; Shomurodova Dilnoza Salimovna

Authors

Mamurova Malikaxon Mirxamzayevna Samarkand State Medical University, Assistant Samarkand State Medical University
Shomurodova Dilnoza Salimovna Doctor of Medical Sciences, Associate Professor Samarkand State Medical University

Keywords:

Discirculatory encephalopathy, renal dysfunction, ultrasound imaging, resistive index, cognitive impairment, MMSE, SDMT, chronic cerebral hypoperfusion, vascular-renal connection, middle age

Abstract

The aim of this study was to determine the association between early signs of renal dysfunction detected by ultrasound imaging (USI) and cognitive impairment in middle-aged patients with discirculatory encephalopathy (DE). The study included 152 participants: the main group (n=56) — patients with DE and renal dysfunction; the comparison group (n=55) — patients with DE without significant renal insufficiency; and the control group (n=41) — healthy individuals.

References

A. K. Akhundov, Dyscirculatory encephalopathy in middle-aged patients: Clinical and neuropsychological aspects. Tashkent, Uzbekistan: Publishing House of the Research Institute of Neurology of Uzbekistan, 2021.

Z. N. Rakhimova and G. S. Mamatova, “Association between chronic kidney disease and cognitive impairment in patients with arterial hypertension,” Bulletin of Neurology and Neurosurgery of Uzbekistan, no. 3, pp. 45–51, 2020.

R. T. Abdurakhmanov, “Ultrasound assessment of renal hemodynamics as an indicator of systemic vascular pathology in patients with arterial hypertension and cognitive impairment,” Clinical Medicine of Uzbekistan, no. 4, pp. 33–39, 2022.

V. A. Sidorov and E. V. Kozlova, “Renal hemodynamics and cognitive impairment in dyscirculatory encephalopathy: Relationship and clinical implications,” Bulletin of Neurology, vol. 17, no. 2, pp. 112–119, 2021.

L. M. Huseynova and T. A. Aliyev, “Renal arterial resistive index as a marker of vascular risk in patients with chronic cerebral ischemia,” S. S. Korsakov Journal of Neurology, vol. 25, no. 4, pp. 58–64, 2020.

S. R. Mukhamedova, “Association between renal dysfunction and progression of dementia in patients with arterial hypertension in Central Asia,” Proceedings of the Tashkent Research Institute of Neurology, vol. 12, pp. 77–83, 2019.

Y. Ko et al., “Renal resistive index as a predictor of cognitive decline in patients with chronic kidney disease and cerebrovascular disease,” Journal of the American Society of Nephrology, vol. 32, no. 6, pp. 1423–1433, 2021, doi: 10.1681/ASN.2020091345.

X. Zhang et al., “Association between renal artery resistance index and white matter hyperintensities in patients with vascular cognitive impairment,” Stroke, vol. 53, no. 1, pp. 154–162, 2022, doi: 10.1161/STROKEAHA.121.036789.

J. H. Bae et al., “Renal dysfunction and cognitive impairment: a bidirectional relationship mediated by endothelial dysfunction,” American Journal of Kidney Diseases, vol. 75, no. 3, pp. 341–350, 2020, doi: 10.1053/j.ajkd.2019.08.017.

C. A. De Jager et al., “The kidney–brain axis: implications for vascular cognitive impairment,” Nature Reviews Nephrology, vol. 15, no. 11, pp. 681–694, 2019, doi: 10.1038/s41581-019-0186-9.

K. Iseki et al., “Association between renal resistive index and cognitive function in elderly patients with hypertension: a cross-sectional study,” Hypertension Research, vol. 44, no. 5, pp. 552–559, 2021, doi: 10.1038/s41440-020-00646-4.

N. I. Tzeng et al., “Cerebrovascular and renal vascular dysfunction: common pathways in vascular cognitive impairment,” Neurobiology of Aging, vol. 88, pp. 1–9, 2020, doi: 10.1016/j.neurobiolaging.2019.12.013.

American Heart Association, “Vascular Cognitive Impairment and Dementia: A Scientific Statement for Healthcare Professionals,” Stroke, vol. 54, no. 1, pp. e1–e26, 2023, doi: 10.1161/STR.0000000000000432.

National Institute for Health and Care Excellence (NICE), Chronic kidney disease: assessment and management (NG196), 2022.

G. M. McKhann et al., “The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging–Alzheimer’s Association workgroups,” Alzheimer’s & Dementia, vol. 7, no. 3, pp. 263–269, 2011, doi: 10.1016/j.jalz.2011.03.005.