Therapy with Muscle Relaxants for Radiculopathies Associated with Spinal Pathology

Nurullaeva Marjona Lutfullo kizi; Maksudova Khurshida Nabievna; Shorakhimov Shakhzod Fakhritdin ugli; Pulatova Madina Maxmudovna

Authors

Nurullaeva Marjona Lutfullo kizi Tashkent State Medical University
Maksudova Khurshida Nabievna Tashkent State Medical University
Shorakhimov Shakhzod Fakhritdin ugli Tashkent State Medical University
Pulatova Madina Maxmudovna Tashkent State Medical University

Keywords:

Vertebrogenic radiculopathy, Centrally acting muscle relaxants, Dorsalgia

Abstract

The article examines the efficacy of centrally acting muscle relaxants (tolperisone, tizanidine, baclofen) in the complex treatment of vertebrogenic radiculopathies. Was to evaluate the impact of muscle relaxants on reducing muscle tone, alleviating pain syndrome, and improving the effectiveness of nerve root decompression. Two groups of patients with MRI-confirmed radiculopathy were examined: the primary group received muscle relaxants in combination with standard therapy, while the control group received standard therapy alone. Assessment was based on the Visual Analog Scale (VAS) and neurological deficit dynamics. It was found that incorporating muscle relaxants into the treatment regimen for 7–14 days facilitates faster regression of muscle-tonic syndrome and restoration of the range of motion. The use of muscle relaxants is pathogenetically justified and significantly increases the effectiveness of complex treatment, especially in cases of severe pain syndrome.

References

F. Abel, F. C. S. Altorfer, V. Rohatgi, W. Gibbs, and J. L. Chazen, “Imaging of discogenic and vertebrogenic pain,” Neurosurg. Clin. N. Am., vol. 36, no. 4, pp. 485–496, 2025.

L. Abril, C. Zamora, M. Cordero, A. R. Williams, and B. W. Friedman, “The relative efficacy of seven skeletal muscle relaxants: An analysis of data from randomized studies,” J. Emerg. Med., vol. 62, no. 4, pp. 455–461, 2022.

M. N. Agzamova, K. F. Zuparov, and T. Z. Zikrilla, “Oxidative status during alloplasty in patients with postoperative ventral hernia,” Infect. Immun. Pharmacol., vol. 1, no. 1, pp. 5–9, 1999.

B. K. Altiev, O. U. Rakhimov, A. D. Kutlimuratov, and U. R. Kasimov, “Intraabdominal bleedings after various options of cholecystectomy,” Vestn. Tashk. Med. Akad., no. 1, pp. 16–19, 2018.

R. Chou et al., “Systemic pharmacologic therapies for low back pain: A systematic review for an American College of Physicians clinical practice guideline,” Ann. Intern. Med., vol. 166, no. 7, pp. 480–492, 2017.

V. Flatow, J. Uy-Kroh, E. T. Carey, C. Ascher-Walsh, and S. Khalil, “Skeletal muscle relaxants for the treatment of myofascial pelvic pain and high tone pelvic floor disorders,” Curr. Opin. Obstet. Gynecol., vol. 35, no. 4, pp. 311–315, 2023.

F. Ismailov and K. Zuparov, “Predicting the severity of peritoneal complications in patients with perforation of hollow organs,” Science, vol. 4, no. 1–4, pp. 129–132, 2025.

C. Schwill, “Back pain in the primary care setting: Specific back pain,” Internist, vol. 62, no. 1, pp. 34–46, 2021.

A. A. Sh and K. F. Zuparov, “The role of oxidative stress and cytokine imbalance in destructive cholecystitis,” in Proc. Int. Congr. Biol., Phys. Chem. Stud., Italy, vol. 8, pp. 71–73, Feb. 2025.

A. A. Sh and K. F. Zuparov, “Immunological changes in destructive cholecystitis,” in Proc. Int. Congr. Biol., Phys. Chem. Stud., Italy, vol. 8, pp. 68–70, Jan. 2025.

A. A. Tursumetov and O. U. Rakhimov, “An innovative approach to the prevention of hemorrhage from the gallbladder bed after cholecystectomy,” Solid State Technol., vol. 63, no. 6, pp. 15231–15245, 2020.

K. F. Zuparov and M. Bozorov, “Non-specific protection factors and the cytokine system in postoperative ventral hernias,” Univ. Index Libr. Innov. Res., vol. 3, no. 11, pp. 150–151, 2024.

K. F. Zuparov, N. Y. Fayzullayeva, and A. A. Tursumetov, “Justification of the expediency of using light propylene nets for onlay plastic surgery of postoperative ventral hernias,” Age (years), vol. 10, pp. 20–39, 2023.

K. F. Zuparov and M. M. Bozorov, “Nonspecific protection factors and the cytokine system in postoperative ventral hernias,” New Day Med., no. 3, pp. 210–214, 2021.