Study Of The Antibacterial Activity And Stability Towards Laser Irradiation Of New Oxazolidine Compounds Derived From Schiff Bases

Asmaa Badr Saber; Rahma Abdel Hamid Hassan Ali

Authors

Asmaa Badr Saber Tikrit university
Rahma Abdel Hamid Hassan Ali Tikrit university

Keywords:

Heterocyclic, Oxazolidines, biological activity, laser

Abstract

In this work, previously synthesized Schiff bases are reacted with glycolic acid using ethanol as a solvent to create heterocyclic pentacyclic rings formed from oxazolidines employing Schiff bases as nuclei. Spectroscopic measurements were used to verify the synthesized compounds' activity. Proton nuclear magnetic resonance, infrared spectroscopy, and quantitative elemental analysis (C.H.N.)—physical measures including melting point, color, and product percentage—are a few examples. Two antibiotic-resistant bacterial isolates—Gram-negative Escherichia coli (Gram-ve) and Gram-positive Staphylococcus aureus (Gram+ve)—were used to assess bioavailability, and the results were compared to controls. The antibiotic comparison reagent (control) was amoxicillin, and the results showed that it had good inhibitory activity against both types of bacteria used with high efficacy and selectivity. The laser activity of the generated compounds was assessed using a visible helium-neon laser. Before being physically exposed, each chemical was exposed to radiation for four distinct times (15, 30, 45, and 60 seconds). The changes in the generated molecules are then recorded.

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