Influence of Hypothyroidism on the Lipid Profile in Patients with Type 2 Diabetes

Turganbaeva Nilufar; Abduraufov  Abdulla; Maksudova  Dilafruzkhon; Dadakhanova  Maryamkhon

doi:10.51699/cajmns.v7i2.3190

Authors

Turganbaeva Nilufar Ordinator of the Department of Endocrinology and Pediatric Endocrinology, Tashkent State Medical University
Abduraufov Abdulla Ordinator of the Department of Endocrinology and Pediatric Endocrinology, Tashkent State Medical University
Maksudova Dilafruzkhon Assistant, Department of Endocrinology and Pediatric Endocrinology, Tashkent State Medical University
Dadakhanova Maryamkhon Assistant, Department of Endocrinology and Pediatric Endocrinology, Tashkent State Medical University

DOI:

https://doi.org/10.51699/cajmns.v7i2.3190

Keywords:

Hypothyroidism, Type 2 Diabetes Mellitus, Dyslipidemia, Lipid Profile, Cardiovascular Risk

Abstract

Type 2 diabetes mellitus and hypothyroidism are among the most common endocrine disorders and frequently coexist in the same patient, forming a clinically significant comorbidity. The combined course of these conditions is associated with pronounced disturbances in lipid metabolism, leading to a substantial increase in cardiovascular risk. This narrative review analyzes current evidence on the impact of overt and subclinical hypothyroidism on the lipid profile in patients with type 2 diabetes mellitus. Key pathophysiological mechanisms of dyslipidemia, clinical features, and the importance of early diagnosis and comprehensive patient management are discussed.

References

World Health Organization, “Diabetes,” WHO Fact Sheets, 2023. Available: https://www.who.int/news-room/fact-sheets/detail/diabetes

A. B. Elhussein and M. H. Ahmed, “Thyroid dysfunction in patients with type 2 diabetes mellitus: Prevalence and metabolic consequences,” Scientific Reports, vol. 15, p. 24465, 2025, doi: 10.1038/s41598-025-24465.

X. Huang, Y. Liu, and Y. Zhang, “Hypothyroidism is associated with dyslipidemia and increased cardiovascular risk in patients with type 2 diabetes mellitus,” Lipids in Health and Disease, vol. 22, p. 112, 2023, doi: 10.1186/s12944-023-01812-9.

H. M. Alnahdi and S. A. Alshammari, “Dyslipidemia in patients with hypothyroidism and type 2 diabetes mellitus,” Saudi Medical Journal, vol. 45, no. 5, pp. 491–496, 2024, doi: 10.15537/smj.2024.45.491.

M. Gierach, J. Gierach, and R. Junik, “Thyroid disorders and lipid metabolism,” Endokrynologia Polska, vol. 66, no. 4, pp. 288–294, 2015, doi: 10.5603/EP.2015.0047.

L. H. Duntas and G. Brenta, “The effect of thyroid disorders on lipid levels and metabolism,” Medical Clinics of North America, vol. 96, no. 2, pp. 269–281, 2012, doi: 10.1016/j.mcna.2012.01.012.

S. H. S. Pearce, G. Brabant, L. H. Duntas, et al., “2013 ETA guideline: Management of subclinical hypothyroidism,” European Thyroid Journal, vol. 2, no. 4, pp. 215–228, 2013, doi: 10.1159/000356507.

J. B. Rugge, C. Bougatsos, and R. Chou, “Screening and treatment of thyroid dysfunction: An evidence review,” JAMA, vol. 313, no. 5, pp. 457–464, 2015, doi: 10.1001/jama.2014.16920.

B. Biondi, A. R. Cappola, and D. S. Cooper, “Subclinical hypothyroidism: A review,” JAMA, vol. 322, no. 2, pp. 153–160, 2019, doi: 10.1001/jama.2019.9052.

American Diabetes Association, “Standards of care in diabetes—2024,” Diabetes Care, vol. 47, suppl. 1, pp. S1–S350, 2024, doi: 10.2337/dc24-Sint.

F. Mach, C. Baigent, A. L. Catapano, et al., “2019 ESC/EAS guidelines for the management of dyslipidaemias,” European Heart Journal, vol. 41, no. 1, pp. 111–188, 2020, doi: 10.1093/eurheartj/ehz455.

International Diabetes Federation, IDF Diabetes Atlas, 10th ed. Brussels, Belgium: International Diabetes Federation, 2023. Available: https://diabetesatlas.org

D. A. Maksudova, "The Relationship Between Thyroid Dysfunction and Dyslipidemia," New Day in Medicine, vol. 5, no. 3, pp. pp. 85-90, 2023.

A. A. Abduraufov and M. Dadakhanova, "Thyroid hormone and lipid metabolism indicators in type 2 diabetes mellitus," Medical Journal of Uzbekistan, vol. 2, no. 1, pp. 47-52, 2022.

Sh. A. Karimov, N. R. Rakhimova, "Features of the Development of Dyslipidemia in the Combination of Diabetes Mellitus and Hypothyroidism," Bulletin of the Tashkent Medical Academy, vol. 3, pp. 96-101, 2021.