Comparison of Morphological and Morphometric Parameters of the Thyroid Gland in Zinc-Deficient White Rats

O.G Aslanov; R.R.  Baymuradov

doi:10.51699/cajmns.v7i1.3044

O.G Aslanov Independent Researcher, Department of Anatomy, Clinical Anatomy (OSTA), Bukhara State Medical Institute named after Abu Ali ibn Sino
R.R. Baymuradov Associate Professor, Department of Anatomy, clinical anatomy (OSTA), Bukhara State Medical Institute named after Abu Ali ibn Sino, PhD

DOI: https://doi.org/10.51699/cajmns.v7i1.3044

Keywords: Zinc deficiency, thyroid gland, morphology, morphometry, microelements, TPO activity, follicular structure, white rats

Abstract

This study analyzes the morphological and morphometric alterations of the thyroid gland in zinc-deficient white rats compared with healthy controls. Zinc deficiency is known to impair thyroid hormone synthesis, transcriptional regulation, and antioxidant defense mechanisms through its essential role in the activity of thyroid peroxidase (TPO) and multiple zinc-dependent metalloenzymes. Experimental findings demonstrated significant changes in capillary parameters, follicular dimensions, epithelial height, stromal composition, and colloid structure under Zn deficiency. These results highlight the critical role of zinc in maintaining thyroid follicular integrity and endocrine homeostasis, confirming the close relationship between microelement balance and thyroid functional status.

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