Evaluating the Role of Interleukin IL-38 Level in Tonsillitis Patients and Relationship with Rheumatoid Arthritis in Diyala Province
DOI:
https://doi.org/10.51699/cajmns.v5i4.2603Keywords:
Rheumatoid arthritis, IL-38, Tonsillitis, Autoimmune Disease, BiomarkerAbstract
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease linked to Streptococcus pyogenes infection, often initiated by tonsillitis or rheumatic fever. This study investigates the relationship between IL-38 levels and the presence of tonsillitis and RA. Conducted from October 2023 to May 2024 in Diyala Governorate, Iraq, 88 participants were categorized into four groups: RA patients, tonsillitis patients, patients with both conditions, and healthy controls. ELISA tests revealed significantly decreased IL-38 levels in RA (63.63 ± 14.45 Pg/ML), tonsillitis (46.97 ± 12.76 Pg/ML), and dual-condition patients (15.18 ± 5.64 Pg/ML) compared to controls (17.16 ± 10.66 Pg/ML). The study highlights IL-38's dual role in disease pathogenesis, suggesting its potential as a biomarker for RA and tonsillitis.
References
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[2] Y. S. Chai, S. H. Lin, M. Zhang, L. Deng, Y. Chen, and K. Xie, et al., "IL-38 Is a Biomarker for Acute Respiratory Distress Syndrome in Humans and Down-Regulates Th17 Differentiation in Vivo," Clinical Immunology, vol. 210, p. 108315, 2020.
[3] A. Diaz-Barreiro, A. Huard, and G. Palmer, "Multifaceted Roles of IL-38 in Inflammation and Cancer," Cytokine, vol. 151, p. 155808, 2022, doi: 10.1016/j.cyto.2022.155808.
[4] G. Y. Enas, "Study of Some Immunological Parameters in Patient That Infected with Streptococcus Pyogenes: Study of Some Immunological Parameters in Patient That Infected with Streptococcus Pyogenes," Iraqi Journal of Market Research and Consumer Protection, vol. 12, no. 1, pp. 128-132, 2020.
[5] E. G. Favalli, M. Biggioggero, C. Crotti, A. Becciolini, M. G. Raimondo, and P. L. Meroni, "Sex and Management of Rheumatoid Arthritis," Clinical Reviews in Allergy & Immunology, 2018, doi: 10.1007/s12016-018-8672-5.
[6] X. Gao, G. Wu, M. S. M. Tsang, D. Huang, C. W. K. Lam, and C. K. Wong, "Novel Insights into the Role of Anti-Inflammatory IL-38 in Immunity Against Infection," Cellular & Molecular Immunology, vol. 19, no. 11, pp. 1322-1324, 2022.
[7] K. Geißler, C. Weigel, K. Schubert, I. Rubio, and O. Guntinas-Lichius, "Cytokine Production in Patients with Recurrent Acute Tonsillitis: Analysis of Tonsil Samples and Blood," Scientific Reports, vol. 10, no. 1, p. 13006, 2020.
[8] S. B. Hassan, H. N. Abdullah, and K. Y. Zakair, "The Role of IL-37 as an Anti-Inflammatory Biomarker in Some Iraqi Rheumatoid Arthritis Patients and Its Correlation with DAS28," Journal of Techniques, vol. 4, Special Issue, pp. 123-127, 2022.
[9] A. W. Haidara, Y. Sidibé, D. Samaké, A. Coulibaly, M. K. Touré, B. B. Coulibaly, S. Soumaoro, B. Guindo, K. Diarra, K. Coulibaly, B. Sanogo, M. Kéïta, and A. A. Mohamed, "Tonsillitis and Their Complications," International Journal of Otorhinolaryngology and Head and Neck Surgery, vol. 8, no. 5, pp. 1205-1211, 2019.
[10] K. J. Brennan, A. Herbert, and E. Byrne, "IL-1 Family Members in Cancer: Two Sides to Every Story," Frontiers in Immunology, vol. 10, p. 1197, 2019, doi: 10.3389/fimmu.2019.01197.
[11] M. N. Khadilkar and N. R. Ankle, "Anaerobic Bacteriological Microbiota in Surface and Core of Tonsils in Chronic Tonsillitis," Journal of Clinical and Diagnostic Research, vol. 10, no. 11, pp. MC01-MC03, 2016.
[12] T. Kindt, R. Goldsby, and B. Osborne, "Rheumatoid Arthritis," in Kuby Immunology, 6th ed., New York, NY: W.H. Freeman and Company, 2007, pp. 401-421.
[13] J. Mora, A. Schlemmer, I. Wittig, F. Richter, M. Putyrski, A.-C. Frank, Y. Han, M. Jung, A. Ernst, A. Weigert, and B. Brüne, "Interleukin-38 is Released from Apoptotic Cells to Limit Inflammatory Macrophage Responses," Journal of Molecular Cell Biology, vol. 8, no. 5, pp. 426-438, Oct. 2016.
[14] F. F. Rija, S. Z. Hussein, and M. A. Abdalla, "Physiological and Immunological Disturbance in Rheumatoid Arthritis Patients," Age (Year), vol. 18, no. 50, pp. 18-50, 2021.
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Published
2024-09-04
How to Cite
Muhammad, R. Q. ., Abbas, A. F. ., & Hassan , I. B. . (2024). Evaluating the Role of Interleukin IL-38 Level in Tonsillitis Patients and Relationship with Rheumatoid Arthritis in Diyala Province. Central Asian Journal of Medical and Natural Science, 5(4), 729–734. https://doi.org/10.51699/cajmns.v5i4.2603
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