Clinical and Laboratory Assessment of the Severity of Urinary Tract Infections in Adolescent Girls Considering Vitamin D Status

Kuryazova Sharofat Masharipovna; Samadova Dilnoza Salakhiddinovna

doi:10.51699/cajmns.v7i3.3256

Authors

Kuryazova Sharofat Masharipovna Tashkent State Medical University
Samadova Dilnoza Salakhiddinovna Tashkent State Medical University

DOI:

https://doi.org/10.51699/cajmns.v7i3.3256

Keywords:

Urinary Tract Infections, Adolescent Girls, Vitamin D Deficiency, 25(OH)D, Recurrent Infection, Inflammation, Pediatric Urology

Abstract

Urinary tract infections in adolescent girls remain a significant pediatric and adolescent health concern because recurrent inflammatory episodes frequently contribute to chronic discomfort, metabolic disturbances, and progressive impairment of local antimicrobial defense mechanisms. The present study aimed to evaluate the clinical and laboratory severity of urinary tract infections depending on vitamin D status in adolescent girls. A total of 55 patients aged 10–18 years underwent comprehensive clinical, laboratory, microbiological, and ultrasonographic examination together with determination of serum 25-hydroxyvitamin D levels. The obtained findings demonstrated that vitamin D deficiency was associated with more severe and recurrent urinary tract infections accompanied by pronounced dysuric disorders, elevated inflammatory markers, anemia syndrome, disturbances of calcium metabolism, and increased prevalence of multidrug-resistant microbial associations. Girls with reduced vitamin D concentrations additionally exhibited higher rates of fungal colonization and persistent inflammatory activity, supporting the important immunomodulatory role of vitamin D in maintaining urothelial protection and antimicrobial resistance.

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