Perinatal Risk Factors in Newborns from Multiple Pregnancies Following in Vitro Fertilization

Ismoilova Malika Azlar  qizi

doi:10.51699/cajmns.v7i3.3253

Authors

Ismoilova Malika Azlar qizi Tashkent State Medical University, 2nd-year Master's Student, Department of Neonatology

DOI:

https://doi.org/10.51699/cajmns.v7i3.3253

Keywords:

in vitro fertilization, multiple pregnancy, neonatal outcomes, perinatal risk factors, prematurity, neonatal intensive care, assisted reproductive technologies

Abstract

Multiple pregnancies remain one of the most challenging conditions in modern obstetrics because they are frequently associated with prematurity, neonatal adaptation disorders, and increased perinatal morbidity, while pregnancies achieved through in vitro fertilization may additionally carry risks related to maternal reproductive history and assisted conception procedures. The present study aimed to compare perinatal risk factors and early neonatal outcomes among newborns delivered from multiple pregnancies after IVF and naturally conceived multiple pregnancies. A comparative clinical analysis was performed using data obtained from 120 newborns divided into two groups according to the method of conception. The results demonstrated that newborns from IVF-associated pregnancies had lower gestational age, reduced birth weight, higher frequency of respiratory distress syndrome, and more frequent admission to neonatal intensive care units. Naturally conceived multiple pregnancies also demonstrated elevated neonatal risks, although complications were comparatively less severe. The findings highlight the necessity for intensified prenatal surveillance and specialized neonatal management in pregnancies following assisted reproductive technologies.

References

J. Qin, H. Wang, X. Sheng, D. Liang, H. Tan, and J. Xia, “Pregnancy-related complications and adverse pregnancy outcomes in multiple pregnancies resulting from assisted reproductive technology: a meta-analysis of cohort studies,” Fertility and Sterility, vol. 115, no. 2, pp. 423–435, 2021.

S. Sunderam, D. M. Kissin, Y. Zhang, et al., “Assisted reproductive technology surveillance — United States, 2022,” MMWR Surveillance Summaries, vol. 73, no. 4, pp. 1–32, 2024.

M. S. Kamath, M. Mascarenhas, R. Kirubakaran, and S. Bhattacharya, “Perinatal outcomes after assisted reproductive technology and natural conception in multiple pregnancies: systematic review and meta-analysis,” Human Reproduction Update, vol. 28, no. 5, pp. 678–695, 2022.

European Society of Human Reproduction and Embryology, “ART fact sheet and European IVF-monitoring consortium report,” Human Reproduction Open, vol. 2023, no. 2, p. hoad018, 2023.

World Health Organization, WHO Recommendations on Interventions to Improve Preterm Birth Outcomes, Geneva, Switzerland: WHO, 2023.

J. P. Vogel, S. Chawanpaiboon, A. B. Moller, K. Watananirun, M. Bonet, and M. Lumbiganon, “The global epidemiology of preterm birth,” Best Practice & Research Clinical Obstetrics & Gynaecology, vol. 79, pp. 3–12, 2022.

L. J. Salomon, Z. Alfirevic, C. M. Bilardo, et al., “ISUOG practice guidelines: role of ultrasound in twin pregnancy,” Ultrasound in Obstetrics & Gynecology, vol. 61, no. 1, pp. 128–145, 2023.

H. Liu, X. Xu, Y. Wang, et al., “Neonatal outcomes of twin pregnancies conceived by assisted reproductive technology versus spontaneous conception: a multicenter cohort study,” Frontiers in Pediatrics, vol. 12, p. 1342281, 2024.

A. Pinborg, U. B. Wennerholm, L. B. Romundstad, et al., “Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis,” Human Reproduction Update, vol. 29, no. 4, pp. 451–469, 2023.

A. Moini, M. Shiva, A. Arabipoor, and R. Hosseini, “Neonatal outcomes in twin pregnancies after assisted reproductive techniques: a comparative cohort study,” BMC Pregnancy and Childbirth, vol. 24, no. 1, p. 118, 2024.

J. F. R. Barrett, M. E. Hannah, E. K. Hutton, et al., “Twin birth outcomes and neonatal morbidity in assisted and spontaneous conception pregnancies,” American Journal of Obstetrics and Gynecology, vol. 227, no. 5, pp. 742–751, 2022.

J. J. Zhang, M. Feret, L. Chang, M. Yang, and Z. Merhi, “Obstetric and neonatal outcomes in multiple pregnancies conceived through assisted reproductive technology,” Journal of Perinatal Medicine, vol. 51, no. 6, pp. 755–764, 2023.

S. Berntsen, V. Söderström-Anttila, U. B. Wennerholm, et al., “The health of children conceived by ART: ‘the chicken or the egg?’,” Human Reproduction Update, vol. 29, no. 2, pp. 137–158, 2023.

S. Pandey, A. Shetty, M. Hamilton, S. Bhattacharya, and A. Maheshwari, “Obstetric and perinatal outcomes in singleton and multiple pregnancies resulting from IVF: an updated systematic review,” BJOG, vol. 129, no. 9, pp. 1458–1472, 2022.

A. C. Rossi and V. D’Addario, “Neonatal outcomes of assisted and naturally conceived twin pregnancies: a comparative meta-analysis,” European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 294, pp. 45–53, 2024.

B. Luke, M. B. Brown, E. Wantman, et al., “The influence of assisted reproductive technology on neonatal morbidity in twin gestations,” Fertility and Sterility, vol. 120, no. 3, pp. 615–624, 2023.