Clinical Characteristics of Early and Late Complications in Newborns Who Experienced Chronic Intrauterine Fetal Hypoxia

Authors

  • Khojimetova Shakhnoza Hasanovna Department of Neonatology, Tashkent State Medical University
  • Gulyamova Muyassar Abdusattarovna Department of Neonatology, Tashkent State Medical University
  • Tursunbayeva Feruza Fazilovna Department of Neonatology, Tashkent State Medical University
  • Ochilova Rozia Ziyadullayevna Department of Neonatology, Tashkent State Medical University

DOI:

https://doi.org/10.51699/cajmns.v7i3.3252

Keywords:

chronic intrauterine hypoxia, newborns, neonatal complications, fetal hypoxia, neurodevelopment, respiratory distress, perinatal pathology

Abstract

Chronic intrauterine fetal hypoxia remains an important cause of neonatal morbidity and long-term developmental disturbances in modern perinatal medicine. The present study aimed to evaluate the clinical characteristics of early and late complications among newborns who experienced prolonged oxygen deficiency during intrauterine life. The investigation included newborn infants delivered from pregnancies complicated by chronic fetal hypoxia and assessed their respiratory adaptation, neurological condition, cardiovascular stability, feeding ability, and developmental outcomes during follow-up observation. The obtained findings demonstrated that respiratory distress syndrome, neurological depression, feeding difficulties, and muscle tone abnormalities were among the most frequent early complications detected after birth. During subsequent pediatric monitoring, several infants additionally developed delayed psychomotor adaptation, sleep disturbances, and neurobehavioral instability. The study confirms that chronic prenatal hypoxia may negatively influence both immediate neonatal adaptation and later neurodevelopmental maturation. Early diagnosis, prolonged pediatric observation, and timely rehabilitation interventions remain essential for improving clinical outcomes and reducing long-term complications in affected children.

References

J. C. Kingdom, M. C. Audette, S. R. Hobson, R. C. Windrim, and E. Morgen, “A placenta clinic approach to the diagnosis and management of fetal growth restriction,” American Journal of Obstetrics and Gynecology, vol. 224, no. 4, pp. 327–338, 2021.

C. A. Herrera and R. M. Silver, “Perinatal asphyxia and hypoxic-ischemic encephalopathy: current concepts and future directions,” Clinics in Perinatology, vol. 49, no. 1, pp. 1–16, 2022.

M. Douglas-Escobar and M. D. Weiss, “Hypoxic-ischemic encephalopathy: a review for the clinician,” JAMA Pediatrics, vol. 175, no. 3, pp. 295–302, 2021.

C. Chollat, L. Sentilhes, and S. Marret, “Fetal hypoxia and brain injury: mechanisms, diagnosis, and prevention,” Seminars in Fetal and Neonatal Medicine, vol. 28, no. 2, p. 101421, 2023.

S. L. Miller, P. S. Huppi, and C. Mallard, “The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome,” The Journal of Physiology, vol. 598, no. 4, pp. 807–823, 2020.

N. Salavati, A. Bakhtiari, and M. Faramarzi, “Long-term neurodevelopmental outcomes in neonates affected by chronic fetal hypoxia,” Children, vol. 9, no. 11, p. 1684, 2022.

D. G. Sweet, V. Carnielli, G. Greisen, et al., “European Consensus Guidelines on the Management of Neonatal Respiratory Distress Syndrome,” Neonatology, vol. 120, no. 1, pp. 3–23, 2023.

C. E. Ahearne, G. B. Boylan, and D. M. Murray, “Short and long term prognosis in perinatal asphyxia: an update,” World Journal of Clinical Pediatrics, vol. 10, no. 3, pp. 67–74, 2021.

J. E. Lawn, E. O. Ohuma, E. Bradley, et al., “Small babies, big risks: global estimates of newborn vulnerability associated with fetal growth restriction and preterm birth,” The Lancet Global Health, vol. 11, no. 9, pp. e1398–e1410, 2023.

L. F. Chalak, F. Tian, T. Tarumi, et al., “Novel approaches for neurodevelopmental monitoring after perinatal hypoxic injury,” Pediatric Research, vol. 91, no. 2, pp. 325–333, 2022.

K. R. Gopagondanahalli, J. Li, M. C. Fahey, et al., “Preterm brain injury and neurodevelopmental outcomes: current perspectives,” Frontiers in Pediatrics, vol. 9, p. 639732, 2021.

R. M. Pressler and B. Mangum, “Newly emerging therapies for neonatal hypoxic-ischemic encephalopathy,” Seminars in Fetal and Neonatal Medicine, vol. 28, no. 3, p. 101436, 2023.

J. S. Jacobs, M. Berg, R. Hunt, et al., “Cooling for newborns with hypoxic ischemic encephalopathy,” Cochrane Database of Systematic Reviews, no. 2, p. CD003311, 2021.

B. Fleiss and P. Gressens, “Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?” The Lancet Neurology, vol. 19, no. 12, pp. 1004–1016, 2020.

J. M. Conway, B. H. Walsh, G. B. Boylan, and D. M. Murray, “Mild hypoxic ischemic encephalopathy and long term neurodevelopmental outcome,” Pediatric Research, vol. 89, no. 2, pp. 282–286, 2021.

K. A. Allen and D. H. Brandon, “Hypoxic ischemic encephalopathy: pathophysiology and experimental treatments,” Newborn and Infant Nursing Reviews, vol. 22, no. 1, pp. 15–22, 2022.

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Published

2026-05-15

How to Cite

Hasanovna, K. S., Abdusattarovna, G. M., Fazilovna, T. F., & Ziyadullayevna, O. R. (2026). Clinical Characteristics of Early and Late Complications in Newborns Who Experienced Chronic Intrauterine Fetal Hypoxia. Central Asian Journal of Medical and Natural Science, 7(3), 145–160. https://doi.org/10.51699/cajmns.v7i3.3252

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