Characteristics of the Neonatal Period in Children Born Small for Gestational Age (Intrauterine Growth Restriction — IUGR

Authors

  • N. D. Ishniyazova The Department of Hospital Pediatrics and Folk Medicine of the Tashkent State Medical University
  • K. Sh. Salikhova The Department of Hospital Pediatrics and Folk Medicine of the Tashkent State Medical University
  • B. U. Agzamkhodzhayeva The Department of Hospital Pediatrics and Folk Medicine of the Tashkent State Medical University
  • F. R. Abdurakhmanova The Department of Hospital Pediatrics and Folk Medicine of the Tashkent State Medical University
  • Z. Ortikmatova The Department of Hospital Pediatrics and Folk Medicine of the Tashkent State Medical University

Keywords:

Intrauterine growth restriction, small for gestational age, neonatal adaptation, respiratory distress syndrome,, hypoglycemia, placental insufficiency, neonatal intensive care

Abstract

Intrauterine growth restriction remains one of the most significant problems in modern neonatology because impaired fetal growth is closely associated with increased neonatal morbidity and disturbances of early postnatal adaptation. The present study was devoted to evaluating the characteristics of the neonatal period in children born small for gestational age with signs of intrauterine growth restriction. Clinical analysis included assessment of anthropometric indicators, respiratory adaptation, metabolic stability, neurological condition, and the frequency of intensive care requirements during the early neonatal period. The obtained findings demonstrated that the majority of examined newborns experienced low birth weight, respiratory distress, hypoglycemia, thermoregulation disorders, and feeding difficulties immediately after birth. Premature infants showed the most severe manifestations of maladaptation and more frequently required specialized neonatal support. The results emphasize the important role of chronic placental insufficiency and fetal hypoxia in the development of neonatal complications and highlight the necessity for early diagnosis, careful prenatal monitoring, and multidisciplinary neonatal management.

References

S. J. Gordijn, I. M. Beune, B. Thilaganathan, et al., “Consensus definition of fetal growth restriction: a Delphi procedure,” Ultrasound in Obstetrics & Gynecology, vol. 57, no. 4, pp. 618–626, 2021.

D. Sharma, N. Farahbakhsh, S. Shastri, and P. Sharma, “Intrauterine growth restriction — part 1,” Journal of Maternal-Fetal & Neonatal Medicine, vol. 35, no. 12, pp. 2313–2327, 2022.

C. C. Lees, T. Stampalija, A. Baschat, et al., “ISUOG practice guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction,” Ultrasound in Obstetrics & Gynecology, vol. 61, no. 2, pp. 267–284, 2023.

F. Figueras and E. Gratacós, “Update on the diagnosis and classification of fetal growth restriction and proposal of a stage-based management protocol,” Fetal Diagnosis and Therapy, vol. 49, no. 1, pp. 1–12, 2022.

S. L. Miller, P. S. Huppi, and C. Mallard, “The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome,” The Journal of Physiology, vol. 601, no. 9, pp. 1741–1758, 2023.

A. Malhotra, B. J. Allison, M. Castillo-Melendez, G. Jenkin, G. R. Polglase, and S. L. Miller, “Neonatal morbidities of fetal growth restriction: pathophysiology and impact,” Frontiers in Endocrinology, vol. 13, p. 842285, 2022.

American College of Obstetricians and Gynecologists, “Fetal growth restriction: ACOG Practice Bulletin No. 227,” Obstetrics & Gynecology, vol. 137, no. 2, pp. e16–e28, 2021.

A. A. Baschat, “Neurodevelopment following fetal growth restriction and its relationship with antepartum parameters of placental dysfunction,” Ultrasound in Obstetrics & Gynecology, vol. 60, no. 3, pp. 306–314, 2022.

F. Crispi, J. Miranda, and E. Gratacós, “Long-term cardiovascular consequences of fetal growth restriction: biology, clinical implications, and opportunities for prevention of adult disease,” American Journal of Obstetrics and Gynecology, vol. 228, no. 2, pp. S869–S879, 2023.

L. M. M. Nardozza, A. C. Caetano, A. C. P. Zamarian, et al., “Fetal growth restriction: current knowledge to the general Obs/Gyn,” Archives of Gynecology and Obstetrics, vol. 305, no. 5, pp. 1065–1077, 2022.

L. M. E. McCowan, F. Figueras, and N. H. Anderson, “Evidence-based national guidelines for the management of suspected fetal growth restriction: comparison, consensus, and controversy,” American Journal of Obstetrics and Gynecology, vol. 224, no. 2, pp. B2–B16, 2021.

E. Murray, M. Fernandes, M. Fazel, S. H. Kennedy, J. Villar, and A. Stein, “Differential effect of intrauterine growth restriction on childhood neurodevelopment: a systematic review,” BJOG, vol. 129, no. 7, pp. 1047–1057, 2022.

J. Miller, S. Turan, and A. A. Baschat, “Fetal growth restriction,” Seminars in Perinatology, vol. 47, no. 1, p. 151632, 2023.

J. C. Kingdom, M. C. Audette, S. R. Hobson, R. C. Windrim, and E. Morgen, “A placenta clinic approach to the diagnosis and management of fetal growth restriction,” American Journal of Obstetrics and Gynecology, vol. 226, no. 2, pp. S803–S817, 2022.

J. Unterscheider, K. O’Donoghue, S. Daly, et al., “Fetal growth restriction and the risk of perinatal morbidity and mortality,” Obstetrics & Gynecology, vol. 137, no. 6, pp. 1117–1126, 2021.

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Published

2026-05-15

How to Cite

Ishniyazova, N. D., K. Sh. Salikhova, B. U. Agzamkhodzhayeva, F. R. Abdurakhmanova, & Z. Ortikmatova. (2026). Characteristics of the Neonatal Period in Children Born Small for Gestational Age (Intrauterine Growth Restriction — IUGR. Central Asian Journal of Medical and Natural Science, 7(3), 139–144. Retrieved from https://cajmns.casjournal.org/index.php/CAJMNS/article/view/3251

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