Synthesis, Study the Antibacterial Activity, Molecular Docking and Liquid Crystals Properties of Some New Heterocyclic Compounds

Safana Awef Abdel  Rahman; Safa Mahmood  Shawkat; Ehab Mohammed  Faraj; Fawzi Hameed  Jumaa

doi:10.51699/cajmns.v7i2.3172

Authors

Safana Awef Abdel Rahman College of Pharmacy, Tikrit University
Safa Mahmood Shawkat Department of Chemistry, College of Science, Tikrit University.
Ehab Mohammed Faraj Salah al-Din Education Directorate
Fawzi Hameed Jumaa Department of Chemistry, College of Education for Women, Tikrit University.

DOI:

https://doi.org/10.51699/cajmns.v7i2.3172

Keywords:

Tetrazole, prepare 2,3-dihydroquinazoline 4-one, 1,3-Oxazepine, 1,3-oxazepane, Molecular docking, Liquid crystal

Abstract

This work involved the synthesis of tetrazole and Hexagonal rings, saturated and unsaturated heptagonal rings azo dye by the reaction of 4,4'-(diazene-1,2-diyl)di aniline with aldehyde group synthesis of Schiff base (S1) in ethanol through the reaction of the substituted amine in THF as a solvent, with sodium azide and synthesis of by reacting Schiff bases with amino benzoic acid to prepare 2,3-dihydroquinazoline 4-one prepared with absolute ethanol as a solvent and using sodium bicarbonate, and preparing 1,3oxazepane4,7-dione through the reaction of succinic anhydride with new Schiff bases, and preparing 1,3oxazepen4,7-dione from During its reaction with maleic anhydride in the existence of dry benzene as a solvent. FT- IR,13CNMR and 1H-NMR Spectrophotometric methods were used to characterize the prepared compounds, the antibacterial activity

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