Ginsenoside Rg1 and Ginseng Alcoholic Extract's Ability to Prevent Tissue Damage and Diabetes-Related Physiological Abnormalities in Male Rats

Bayan Mohammed Mahdi Almubarak

doi:10.51699/cajmns.v7i2.3101

Authors

Bayan Mohammed Mahdi Almubarak Department of Biology, College of Education for Pure Sciences, Kirkuk University, Kirkuk, Iraq

DOI:

https://doi.org/10.51699/cajmns.v7i2.3101

Keywords:

Diabetes mellitusn, Ginsenoside, Inflammatory cytokines, IL-6 and TNF-α

Abstract

Because diabetes upsets the oxidative equilibrium, it increases the risk of hepatic tissue problems. There aren't many efficient therapies available for this common ailment right now. Because ginseng extract and ginsenosides are known to have anti-inflammatory, anti-apoptotic, and antioxidant qualities, this study sought to investigate their potential use as a natural medicine. Eight groups of male rats were used. Distilled water, 200 mg/kg of ginseng alcoholic extract, 25 mg/kg of ginsenosides, and a combination of 200 mg/kg of ginseng alcoholic extract and 25 mg/kg of ginsenosides were given to each of the first four groups. The first group was in good health. Distilled water was provided to the fifth group, 200 mg/kg of ginseng alcoholic extract was given to the sixth, 25 mg/kg of ginsenosides were given to the seventh, and both 200 mg/kg of ginseng alcoholic extract and 25 mg/kg of ginsenosides were given to the eighth. All four of the other groups had diabetes. The animals were put to death after 30 days so that their livers could be removed for histological analysis and blood could be taken for biochemical research. The diabetes group had higher levels of MDA and IL-6, lower levels of GSH, and a higher frequency of liver histological abnormalities as compared to the healthy control group. The groups given only ginseng alcoholic extract, ginsenosides, and a combination of ginseng alcoholic extract and ginsenosides showed improvements in liver histology, decreased levels of MDA and IL-6, and increased levels of GSH when compared to the diabetic group. According to the study's findings, there is a stronger synergistic impact when ginseng alcoholic extract and ginsenosides are used together as opposed to separately.

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