Clinical Laboratory Prognostic Markers Evaluation for Onset Identification of Arrhythmia Complications in Diwaniyah City

Noor Ali  Gebur

doi:10.51699/cajmns.v7i1.3093

Authors

Noor Ali Gebur Department of Chemistry, College of Science, University of Al-Qadisiyah, Diwaniyah, Iraq.

DOI:

https://doi.org/10.51699/cajmns.v7i1.3093

Keywords:

Arrhythmia, NGAL, Oxidative Stress

Abstract

Arrhythmia refers to an irregular heartbeat that may be too fast, too slow, or uneven. NGAL, a protein classified as an acute-phase reactant. Assess NGAL levels in serum of individuals with arrhythmia, this was the aim of our study, also to find associations with other markers. An action study including 120 participants, from Iraq, Diwaniyah city, 60 patients with arrhythmia, the results was compared with 60 healthy as control. Serum levels of NGAL and various metabolic markers including K⁺, SOD, in addition to GPx, and D-dimer were measured in all subjects. Statistical analyses were performed to compare the two groups and evaluate correlations among the investigated parameters. The statistical evaluation revealed a significantly decline in serum SOD, K⁺ , GPx levels in group of the arrhythmia as compared to the group of control. Serum levels of NGAL and D-dimer was a significantly increased in individuals with arrhythmia as compared to the control group. NGAL levels in this findings revealed a strong significant inverse correlations with K⁺, SOD and GPx levels, while a strong significant direct correlation with D-dimer levels. The present study demonstrated that individuals with arrhythmia exhibited a significantly elevated serum NGAL levels as compared to the group of control. In the turn, NGAL had a significant strong inverse relationship with (SOD, K⁺, GPx) and a significant strong direct relationship with D- dimer, these findings suggest that NGAL levels may serve a protective function during the early stages of cellular dysfunction associated with arrhythmia, contributing to stroke pathogenesis.

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