Application of Specialized Amino Acid Solutions in Intensive Care Therapy of Sepsis

Atashov Aybek Raimberganovich; Nurullaeva Gulmira  Amudullaevna; Urinboev Tolibjon Ganjaboy  ugli

doi:10.51699/cajmns.v6i4.2945

Atashov Aybek Raimberganovich Associate Professor, Candidate of Medical Sciences, Department of Pediatric Surgery, Anesthesiology and Resuscitation
Nurullaeva Gulmira Amudullaevna Master’s Student in Anesthesiology and Resuscitation, Department of Pediatric Surgery, Anesthesiology and Resuscitation, Tashkent Medical Academy, Urgench Branch
Urinboev Tolibjon Ganjaboy ugli Master’s Student in Anesthesiology and Resuscitation, Department of Pediatric Surgery, Anesthesiology and Resuscitation, Tashkent Medical Academy, Urgench Branch

DOI: https://doi.org/10.51699/cajmns.v6i4.2945

Keywords: Sepsis, Intensive Care, Amino Acids, Glutamine, Arginine, Parenteral Nutrition

Abstract

Sepsis remains one of the leading causes of mortality in intensive care units. Metabolic disorders, protein catabolism, and deficiency of certain amino acids worsen the course of the disease. In recent years, the role of specialized amino acid solutions aimed at correcting metabolic disturbances and modulating the immune response has been actively studied. The most important amino acids are glutamine, arginine, cysteine, ornithine, and taurine, which have pronounced antioxidant, immunomodulatory, and endothelioprotective properties. This review summarizes current data on the use of amino acid solutions in intensive care therapy of sepsis, their impact on outcomes, and perspectives for further use.

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