Effectiveness of Ulinastatin in Combination with Amino Acid Solutions in Patients with Sepsis

Gulmira Amudullaevna Nurullaeva; Aybek Raimberganovich  Atashov; Tolibjon Ganjaboy ugli  Urinboev

doi:10.51699/cajmns.v6i4.2944

Gulmira Amudullaevna Nurullaeva Master’s Student in Anesthesiology and Resuscitation, Department of Pediatric Surgery, Anesthesiology and Resuscitation, Tashkent Medical Academy, Urgench Branch (TMAUB)
Aybek Raimberganovich Atashov Associate Professor, Candidate of Medical Sciences, Department of Pediatric Surgery, Anesthesiology and Resuscitation, TMAUB
Tolibjon Ganjaboy ugli Urinboev Master’s Student in Anesthesiology and Resuscitation, Department of Pediatric Surgery, Anesthesiology and Resuscitation, Tashkent Medical Academy, Urgench Branch (TMAUB)

DOI: https://doi.org/10.51699/cajmns.v6i4.2944

Keywords: Sepsis, Obstetric Sepsis, Ulinastatin, Amino Acid Solutions, Cytokines, IL-6, TNF-Α, SOFA, Intensive Care

Abstract

Sepsis remains one of the leading causes of mortality in intensive care units, particularly in obstetric pathology. Despite advances in modern treatment methods, mortality rates remain high due to the complex pathogenesis of sepsis. The systemic inflammatory response, characterized by excessive production of pro-inflammatory cytokines such as IL-6 and TNF-α, plays a central role in the development of multiple organ dysfunction. Ulinastatin, a protease inhibitor with pronounced anti-inflammatory and organ-protective properties, has shown promise in modulating the inflammatory cascade. At the same time, specialized amino acid solutions provide metabolic support, improve nitrogen balance, and restore immune function. The combined use of ulinastatin and amino acid solutions may represent a synergistic therapeutic strategy. This study evaluates the clinical efficacy of this combination in patients with sepsis based on cytokine dynamics, organ dysfunction (SOFA score), and mortality outcomes.

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