Evaluation of Immune Response of   Staphylococcus aureus Isolated from Periodontitis

Suhair M. Jabbar; Haider H.  Mitab; Ali G.  Al-Dulimi

doi:10.17605/cajmns.v6i4.2909

Suhair M. Jabbar College of Nursing, Al Muthanna University, Al-Samawah City, Iraq.
Haider H. Mitab College of Nursing, Al Muthanna University, Al-Samawah City, Iraq.
Ali G. Al-Dulimi Colleges of Dentistry, University of Bilad Alrafidain, Diyala City, Iraq.

DOI: https://doi.org/10.17605/cajmns.v6i4.2909

Keywords: Periodontitis, Staphylococcus aureus, Immune response, Susceptibility test, TLR-2, IL-4, IL-10, IL-17serum level

Abstract

The present study aims to evaluate the immune response of S. aureus isolated from Periodontitis, which can cross from the oral cavity and lead to systemic inflammation, The isolation and identification of Staphylococcus aureus was carried out from twenty patients suffering from Periodontitis with an susceptibility test to estimate the isolated bacteria. The immune response was determined in albino mice serum, specifically for TLR-2, IL-4, IL-10, and IL-17 levels. Susceptibility test results showed that the rate of resistance of isolates to antibiotics varied. The immunological study revealed a difference in cytokine values between the present study groups when stimulated with S. aureus. The results showed that TLR-2, IL-4, IL-10, and IL-17 levels estimations were 9.38, 136.56, 98.6, and 288.3 pg/mL, respectively, with significant differences at p < .05. The conclusions were that S. aureus can affect the immune system of lab mice with Periodontitis and then systemic cytokine progression.

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