Synthesis and Characterization of the 1,3- Oxazepine Derivatives
Keywords:
1,3- Oxazepine, Schiff-bases, DMF, Maleic anhydride, phthalic anhydride
Abstract
The Study Included The synthesis of some new heterocyclic compounds such as 1,3-Oxazepines from reaction between malic anhydride with Schiff bases in the precence of some drops of glacial acetic acid. Schiff-base (c1-c2) were prepared from the raction of aromatic aldehyde with aromatic amines and then reacted with maleic anhydride and phthalic Anhydride to produce new compounds 1,3- oxazepine derivatives The synthesized compounds have been characterization by the determination physical properties as such as m.p.c and the spectroscopy methods such as FlT-IR, 1H-NMR, 13C-NMR.
References
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15. Mohammad, K. M., Ahmed, M. R., & Mahmoud, M. H. (2017). Synthesis and characterization of some new (1, 3-Oxazepine) derivative from 6-methyl 2-thiouracil and study their biological activity. Tikrit Journal of Pure Science, 22(2), 67-81.
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2. Cho, S. H., Kim, J. Y., Kwak, J., & Chang, S. (2011). Recent advances in the transition metal-catalyzed twofold oxidative C–H bond activation strategy for C–C and C–N bond formation. Chemical Society Reviews, 40(10), 5068-5083.
3. Majeed, N. S., & Rahim, Z. H. (2023).SYNTHESIS AND CHARACTERIZATION OF SOME HETEROCYCLIC COMPOUNDS (AZETIDINE, OXAZEPINE) DERIVED FROM SCHIFF BASES AND EVALUATION OF THEIR BIOLOGICAL ACTIVITY. Article History. University of Kufa, Iraq. , 12, (S3), 3764 – 377.
4. Rahman, L. H. A., Abu-Dief, A. M., Hashem, N. A., & Seleem, A. A. (2015). Recent advances in synthesis, characterization and biological activity of nano sized Schiff base amino acid M (II) complexes. Int. J. Nano. Chem, 1(2), 79-95.
5. Mukhlif, M. G., Al-Asafi, O. J. M., & Alywee, A. K. (2023, February). Formation of new substituted (1, 3) oxazepine 1, 5-diones via reaction of Exo-3, 6-epoxy-1, 2, 3, 6-tetrahydrophthalic Anhydride with Schiff’s bases. In AIP Conference Proceedings (Vol. 2457, No. 1). AIP Publishing.
6. Sallal, Z. A., & Ghanem, H. T. (2018). Synthesis and Identification of New Oxazepine Derivatives bearing Azo group in their structures. Iraqi Journal of Science, 1-8.
7. Moawad, E. B. (1989). Synthesis of some new heterocyclic compounds with expected potential biological activity. Journal of Islamic Academy of Sciences, 2(4), 237-240.
8. Abbas, A. K., & Jber, N. R. (2020). Synthesis and Estimation of Biological Activity of New Oxazepine Derivatives. International Journal of Pharmaceutical Research, 12(2), 3750-3758
9. Hassan, S. A., Aziz, D. M., Abdullah, M. N., Bhat, A. R., Dongre, R. S., Ahmed, S., ... & Jamalis, J. (2023). Design and Synthesis of Oxazepine Derivatives from Sulfonamide Schiff bases as Antimicrobial and Antioxidant agents with low Cytoxicity and Hemolytic Prospective. Journal of Molecular Structure, 136121
10. W Adam, R., & Zimam, E. H. (2014). Synthesis, characterization and study biological activity of some new 1, 3- oxazepine and 1, 3-diazepine derivatives. karbala journal of pharmaceutical sciences, 5(7), 195-217.
11. Hello, K. M. (2006). Synthesis of New Derivatives of N-Substituted Saccharin Via Glycine Derivatives. Iraqi National Journal Of Chemistry, (24).
12. Mahdi, H. A., Abbas, K. S., &Dagher, H. M. Synthesis, Characterization and Anti-hyperglycemic Activity of some novel Formazans Derivatives. Synthesis, (2015); 7(12)
13. Jasim, S. S. (2019). Synthesis, Characterization and Evaluation Antibacterial Activity of Some Schiff Bases and (1, 3-Oxazepine or Diazepine-4, 7-Dione). Kirkuk University Journal-Scientific Studies, 14(2), 249-272.
14. Al-Juburi, R. M. (2012). Synthesis and characterization of some heterocyclic compounds (oxazepine, tetrazole) derived from Schiff bases. Al-Nahrain Journal of Science, 15(4), 60-67.
15. Mohammad, K. M., Ahmed, M. R., & Mahmoud, M. H. (2017). Synthesis and characterization of some new (1, 3-Oxazepine) derivative from 6-methyl 2-thiouracil and study their biological activity. Tikrit Journal of Pure Science, 22(2), 67-81.
16. A Kherallah, B. (2014). Synthesis and Identification of some 1, 3-oxazepine derivatives containing pmethoxy phenyl and studying their anti bacterial activity. karbala journal of pharmaceutical sciences, 5(7), 31-41.
17. Nadr, R. B., & Abdulrahman, B. S. (2023). Synthesis and Characterization of a New Series of [1, 3]- Oxazepine Compounds from Heterocyclic Schiff Bases. Zanco Journal of Pure and Applied Sciences, 35(2), 197-210
Published
2023-10-31
How to Cite
Haneen. J. Mohammed, & M. S. Magtoof. (2023). Synthesis and Characterization of the 1,3- Oxazepine Derivatives. Central Asian Journal of Medical and Natural Science, 4(5), 1035-1044. https://doi.org/10.51699/cajmns.v4i5.1965
Section
Articles
